Mouse
Core
Drugs that pass the iPSC Organoid Core reaches the TRIDENT Mouse Core. Distributed at two renowned Canadian institutions, Western University and the University of Toronto. The Mouse Core is being established to create improved humanized models of neurodegenerative diseases and to establish clinically relevant molecular and cognitive biomarkers that can be used for evaluation of therapeutics across species using assays that are routinely used for human patients. Therefore, the drugs will be evaluated in humanized mouse models of neurodegenerative diseases and also by using humanized assays, positioning the drugs that pass this screen to be successful for higher model testing.
TRIDENT is committed to the highest standards of animal care in research.
Current Models
Alzheimer's Diesase
α-Synucleinopathy
MEET THE TEAM
DR. TIM BUSSEY
TRIDENT Co-Principal Investigator
and Cognition Biomarker Team Lead
Professor, Physiology and Pharmacology,
The Schulich School of Medicine & Dentistry,
Western University
Western Research Chair in
Cognitive Neuroscience
Director, BrainsCAN Rodent Cognition
and Innovation Core
Email:
​​
DR. MALLAR CHAKRAVARTY
TRIDENT Co-Principal Investigator, Data Management & Sharing Core Team Lead, Imaging Biomarker Team Lead
Associate Professor, Department of Psychiatry, McGill University
Director, Researcher, and Computational Neuroscientist, Brain Imaging Centre,
Douglas Research Centre
Associate Member, Department of Biomedical Engineering, McGill University
Email:
​​Website:
https://www.cobralab.ca/mallar-chakravarty
DR. RAVI MENON
TRIDENT Principal Investigator
and Imaging Biomarker Team Lead
Professor, Departments of Medical Biophysics, Medical Imaging, Neuroscience, and Psychiatry,
Western University
Canada Research Chair in
Functional and Molecular Imaging
Research Scientist, CFMM
Co-Scientific Director of BrainsCAN
​Email:
​​
Website:
https://cfmm.uwo.ca/people/core_scientists/ravi_menon.html
DR. MARCO PRADO
TRIDENT Co-Principal Investigator
and Molecular Biomarker Team Lead
Professor, Department of Physiology and
Pharmacology and Department of Anatomy
& Cell Biology
Scientist, Robarts Research Institute
Canada Research Chair in Neurochemistry
of Dementia
Deputy Editor in Chief Journal of Neurochemistry
Email:
​​
https://www.schulich.uwo.ca/physpharm//people/faculty/prado_marco.html
DR. VANIA PRADO
TRIDENT Co-Principal Investigator
and Mouse Imaging Team Lead
Professor, (cross appointment with Physiology and Pharmacology
and Robarts Research Institute)
​Email:
​​
Website:
https://www.schulich.uwo.ca/anatomy//people/faculty/faculty_members/prado_vania.html
DR. LISA SAKSIDA
TRIDENT Co-Principal Investigator and
Imaging Biomarker Team Lead
Professor, Physiology and Pharmacology
The Schulich School of Medicine & Dentistry, Western University
Tier 1 Canada Research Chair in Translational Cognitive Neuroscienc
Co-Scientific Director, BrainsCAN
​
Email:
​​Website:
DR. JOEL WATTS
TRIDENT Co-Principal Investigator
and Mouse Team Lead
Associate Professor,
Department of Biochemistry,
University of Toronto
Principal Investigator,
Tanz Centre for Research in
Neurodegenerative Diseases
Email:
​​
https://joelwattslab.org​​
